Mirgorodskaia O A, Olsuf'eva E N, Kolume D E, Joergensen T J, Roepstorff P, Pavlov A Iu, Miroshnikova O V, Preobrazhenskaia M N
Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.
Bioorg Khim. 2000 Aug;26(8):631-40.
The dimerization constants for glycopeptide antibiotics vancomycin, ristocetin, and eremomycin and nine semisynthetic eremomycin derivatives were determined by the electrospray ionization mass spectrometry; the constants for natural antibiotics turned out to be close to those previously determined by NMR. No correlation between these dimerization constants and antibacterial activities of all the compounds toward the clinical strains of Gram-positive bacteria was found.
通过电喷雾电离质谱法测定了糖肽类抗生素万古霉素、瑞斯托菌素、厄他培南霉素以及九种半合成厄他培南霉素衍生物的二聚常数；结果发现天然抗生素的常数与先前通过核磁共振测定的常数相近。未发现这些二聚常数与所有化合物对革兰氏阳性菌临床菌株的抗菌活性之间存在相关性。
