Fang J T, Chen Y C
Department of Nephrology, Chang Gung Memorial Hospital, Chang Gung University Taipei, Taiwan.
Ren Fail. 2000;22(5):647-52. doi: 10.1081/jdi-100100906.
Tubulointerstitial involvement is well recognized in systemic lupus erythematosus. The tubular dysfunction is usually latent and usually presents after diagnosis of systemic lupus erythematosus. We report a case presenting that she is well previously and initially diagnosed as periodic paralysis of hypokalemia at emergency room and final diagnosis is systemic lupus erythematosus with H+-ATPase pump defect of distal type renal tubular acidosis. Kidney biopsy showed lupus nephritis classified as mesangial proliferative glomerulonephritis WHO class II B. Her renal tubular acidosis was subsided after steroid therapy was administered.
肾小管间质受累在系统性红斑狼疮中已得到充分认识。肾小管功能障碍通常是潜伏性的，通常在系统性红斑狼疮诊断后出现。我们报告一例病例，患者此前情况良好，在急诊室最初被诊断为低钾性周期性麻痹，最终诊断为系统性红斑狼疮伴远端肾小管酸中毒的H⁺-ATP酶泵缺陷。肾活检显示狼疮性肾炎，WHO分类为系膜增生性肾小球肾炎II B级。给予类固醇治疗后，她的肾小管酸中毒得到缓解。
