Tamaoka A, Matsuno S, Ono S, Shimizu N, Shoji S
Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
J Neurol. 2000 Aug;247(8):633-5. doi: 10.1007/s004150070133.
Distinct vascular and periadnexal immunoreactivity have been observed for amyloid b protein (Abeta) in skin from patients with amyotrophic lateral sclerosis (ALS). We used an enzyme-linked immunosorbent assay to make a more quantitative comparison of Abeta concentrations between ALS patients and controls. The insoluble fractions of skin samples from ALS patients contained significantly higher Abeta concentrations per milligram protein than those from controls. Various alterations in extracellular matrix components have been reported to occur in the skin of patients with ALS, and several matrix constituents have been shown to affect processing and aggregation of Abeta in human brain. Taking these previous findings together with those of the present study, our observations suggest that changes in extracellular matrix in skin of ALS patients may facilitate aggregation and deposition of Abeta.
在肌萎缩侧索硬化症（ALS）患者的皮肤中，已观察到淀粉样β蛋白（Abeta）在血管和附件周围有明显的免疫反应性。我们使用酶联免疫吸附测定法对ALS患者和对照组之间的Abeta浓度进行了更定量的比较。ALS患者皮肤样本的不溶性部分每毫克蛋白质中的Abeta浓度显著高于对照组。据报道，ALS患者的皮肤中细胞外基质成分发生了各种改变，并且已表明几种基质成分会影响人脑中Abeta的加工和聚集。将这些先前的发现与本研究的发现结合起来，我们的观察结果表明，ALS患者皮肤中细胞外基质的变化可能促进Abeta的聚集和沉积。
