Bavister B D, Squirrell J M
Department of Animal Health & Biomedical Sciences, University of Wisconsin-Madison, 53706, USA.
Hum Reprod. 2000 Jul;15 Suppl 2:189-98. doi: 10.1093/humrep/15.suppl_2.189.
Active mitochondria relocate during oocyte maturation or fertilization in several species. Detailed studies with hamster oocytes and early embryos reveal a pattern of active mitochondria migrating to surround the pronuclei to form a pattern that persists through the early cleavage stages. Although the functional significance of this relocation is unknown, it appears to be an important part of normal development in hamsters. Treatments that disrupt embryo development in vitro (such as the presence of inorganic phosphate or alteration of intracellular pH) also disrupt the normal pattern of mitochondrial distribution. Active mitochondria also reorganize during maturation in bovine oocytes and during fertilization in rhesus monkey oocytes. Examination of these changes in mitochondrial organization may provide insights into the regulation of normal embryo development and might serve as predictors of oocyte or embryo developmental competence.
在多个物种中，活跃的线粒体在卵母细胞成熟或受精过程中会重新分布。对仓鼠卵母细胞和早期胚胎的详细研究揭示了一种活跃线粒体迁移并围绕原核形成一种模式的现象，这种模式会持续到早期卵裂阶段。尽管这种重新分布的功能意义尚不清楚，但它似乎是仓鼠正常发育的重要组成部分。在体外干扰胚胎发育的处理（如无机磷酸盐的存在或细胞内pH值的改变）也会破坏线粒体分布的正常模式。活跃的线粒体在牛卵母细胞成熟过程中以及恒河猴卵母细胞受精过程中也会重新组织。对线粒体组织这些变化的研究可能有助于深入了解正常胚胎发育的调控机制，并可能作为卵母细胞或胚胎发育能力的预测指标。
