Pantanowitz L, Omar T, Sonnendecker H, Karstaedt A S
Department of Medicine, Chris Hani Baragwanath Hospital and South African Institute for Medical Research, University of Witwatersrand, Johannesburg, South Africa.
J Infect. 2000 Jul;41(1):92-4. doi: 10.1053/jinf.2000.0667.
To describe the bone marrow lesions in eight cases of Cryptococcus neoformans infection involving the bone marrow in HIV-infected patients.
Archival bone marrow biopsies from patients with HIV-related cryptococcosis of the bone marrow were retrospectively reviewed. Cryptocococcal organisms were identified on haematoxylin- and eosin-stained slides and confirmed using mucicarmine staining.
Yeast cells stimulated a granulomatous response in all cases despite immunosuppression. The number of cryptococcal organisms appeared to be inversely proportional to the adequacy of the granulomatous response. All patients had a cytopenia.
The ability to mount a tissue response in order to localize organisms is retained in patients with AIDS. Infection of the bone marrow with cryptococci may act in synergy with HIV to cause cytopenia.
描述8例HIV感染患者中新型隐球菌感染累及骨髓的骨髓病变情况。
回顾性分析HIV相关骨髓隐球菌病患者的存档骨髓活检标本。在苏木精-伊红染色切片上识别新型隐球菌，并通过黏液卡红染色进行确认。
尽管存在免疫抑制，但酵母细胞在所有病例中均引发了肉芽肿反应。新型隐球菌的数量似乎与肉芽肿反应的充分程度呈反比。所有患者均有血细胞减少。
艾滋病患者仍保留产生组织反应以局限病原体的能力。骨髓隐球菌感染可能与HIV协同作用导致血细胞减少。
