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通过髂骨骨髓穿刺分析诊断播散性隐球菌病。

Diagnosis of disseminated cryptococcosis via iliac bone marrow aspirate analysis.

作者信息

Chen Weibu, Chen Xueyan

机构信息

Laboratory Department, Shenzhen People's Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong, PR China.

Clinical Laboratory, Department of Clinical Laboratory, Shenzhen Longhua District People's Hospital, Shenzhen, PR China.

出版信息

IDCases. 2024 Dec 16;39:e02136. doi: 10.1016/j.idcr.2024.e02136. eCollection 2025.

DOI:10.1016/j.idcr.2024.e02136
PMID:39807302
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11728956/
Abstract

HIV infection frequently affects multiple systems, with hematological manifestations being the most prevalent. In some cases, cryptococcosis serves as the initial manifestation and a cause of infection involving HIV-positive patients. This case report describes a patient with thrombocytopenia who incidentally discovered infiltrating the bone marrow upon bone marrow smear examination, highlighting that examining bone marrow is essential in diagnosing pancytopenia resulting from opportunistic fungal infections like cryptococcosis, especially in individuals with compromised immune systems.

摘要

HIV感染常累及多个系统，血液学表现最为常见。在某些情况下，隐球菌病是HIV阳性患者感染的初始表现及病因。本病例报告描述了一名血小板减少症患者，其在骨髓涂片检查时偶然发现骨髓有浸润，强调了骨髓检查对于诊断由隐球菌病等机会性真菌感染导致的全血细胞减少至关重要，尤其是在免疫系统受损的个体中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef38/11728956/5baef3983af6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef38/11728956/5baef3983af6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef38/11728956/5baef3983af6/gr1.jpg

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Diagnosis of disseminated cryptococcosis via iliac bone marrow aspirate analysis.通过髂骨骨髓穿刺分析诊断播散性隐球菌病。
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本文引用的文献

1
Diagnostic accuracy of metagenomic next-generation sequencing for cryptococcosis in immunocompetent and immunocompromised patients.免疫功能正常和免疫功能低下患者隐球菌病的宏基因组下一代测序的诊断准确性。
Front Cell Infect Microbiol. 2022 Oct 20;12:997256. doi: 10.3389/fcimb.2022.997256. eCollection 2022.
2
Progressive Cytopenia Developing during Treatment of Cryptococcosis in a Patient with HIV Infection and Bone Marrow Cryptococcal Infection.HIV 感染者伴骨髓隐球菌感染患者在隐球菌病治疗过程中出现进行性血细胞减少症。
Intern Med. 2022 Jan 15;61(2):257-261. doi: 10.2169/internalmedicine.7282-21. Epub 2021 Jul 30.
3
Invasive fungal infection by Cryptococcus neoformans var. grubii with bone marrow and meningeal involvement in a HIV-infected patient: a case report.
新型隐球菌变种格卢氏菌骨髓和脑膜侵犯合并 HIV 感染患者的侵袭性真菌感染：一例报告。
BMC Infect Dis. 2019 Mar 4;19(1):220. doi: 10.1186/s12879-019-3831-8.
4
Unraveling synthesis of the cryptococcal cell wall and capsule.解析隐球菌细胞壁和荚膜的合成。
Glycobiology. 2018 Oct 1;28(10):719-730. doi: 10.1093/glycob/cwy030.
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Integrated therapy for HIV and cryptococcosis.HIV与隐球菌病的综合治疗
AIDS Res Ther. 2016 Nov 29;13(1):42. doi: 10.1186/s12981-016-0126-7.
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Disseminated cryptococcosis in bone marrow.骨髓播散性隐球菌病
Blood. 2014 May 15;123(20):3070. doi: 10.1182/blood-2014-01-553941.
7
Cryptococcososis of bone marrow: a case report with review of literature.骨髓隐球菌病：一例报告并文献复习
J Clin Diagn Res. 2014 Jan;8(1):158-9. doi: 10.7860/JCDR/2014/6478.3807. Epub 2014 Jan 12.
8
Bone Marrow Abnormalities in HIV Disease.HIV 病中的骨髓异常。
Mediterr J Hematol Infect Dis. 2013 Jun 3;5(1):e2013033. doi: 10.4084/MJHID.2013.033. Print 2013.
9
Acquired immunodeficiency syndrome presenting as marrow cryptococcosis.获得性免疫缺陷综合征表现为骨髓隐球菌病。
Indian J Pathol Microbiol. 2010 Oct-Dec;53(4):904-6. doi: 10.4103/0377-4929.72069.
10
Cryptococcal granulomas in an immunocompromised HIV-negative patient.一名免疫功能低下的HIV阴性患者的隐球菌肉芽肿
Indian J Pathol Microbiol. 2008 Oct-Dec;51(4):553-5. doi: 10.4103/0377-4929.43760.