Peart W S
Clin Nephrol. 1975 Oct;4(4):138-43.
The history of the development of ideas on the cause of renal hypertension is first discussed. Growth of knowledge of renin and angiotensin from 1898 to the present is shown to depend upon better and more specific assays for each part of the system, which has enabled knowledge of the role of the renin-angiotensin system in various forms of hypertension to be assessed accurately. The difficulties of assessing varying levels in relation to their biological effect is stressed and the importance of the use of blockers of both renin and angiotensin is shown to mark a very large advance in the study of various forms of renal hypertension where there is a complicated relationship, still ill-defined, between renin, angiotensin, sodium and body fluid volumes.
本文首先讨论了肾性高血压病因相关理论的发展历程。从1898年至今，肾素和血管紧张素知识的增长依赖于对该系统各部分更完善、更具特异性的检测方法，这使得人们能够准确评估肾素 - 血管紧张素系统在各种高血压形式中的作用。文中强调了评估与生物效应相关的不同水平的困难，并表明使用肾素和血管紧张素阻滞剂在各种肾性高血压研究中取得了巨大进展，在这些研究中，肾素、血管紧张素、钠和体液容量之间存在复杂且仍不明确的关系。
