高尔基体的核苷酸糖转运体。
Nucleotide sugar transporters of the Golgi apparatus.
作者信息
Berninsone P M, Hirschberg C B
机构信息
Department of Molecular and Cell Biology, Boston University, School of Dental Medicine, 700 Albany Street, W-200, MA 02118, Boston, USA.
出版信息
Curr Opin Struct Biol. 2000 Oct;10(5):542-7. doi: 10.1016/s0959-440x(00)00128-7.
Abstract
Glycosylation, sulfation and phosphorylation of proteins, proteoglycans and lipids occur in the lumen of the Golgi apparatus. The nucleotide substrates of these reactions must be first transported from the cytosol into the Golgi lumen by specific transporters. The topology and structure of these hydrophobic, multi-transmembrane-spanning proteins are beginning to be understood.
摘要
蛋白质、蛋白聚糖和脂质的糖基化、硫酸化和磷酸化发生在高尔基体腔内。这些反应的核苷酸底物必须首先通过特定的转运蛋白从细胞质溶胶转运到高尔基体腔内。这些疏水的、跨多个跨膜结构域的蛋白质的拓扑结构和结构正逐渐被人们所了解。
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