Sauer F G, Barnhart M, Choudhury D, Knight S D, Waksman G, Hultgren S J
Department of Molecular Microbiology, Washington University School of Medicine, Missouri 63110, St Louis, USA.
Curr Opin Struct Biol. 2000 Oct;10(5):548-56. doi: 10.1016/s0959-440x(00)00129-9.
Bacterial pili assembled by the chaperone-usher pathway can mediate microbial attachment, an early step in the establishment of an infection, by binding specifically to sugars present in host tissues. Recent work has begun to reveal the structural basis both of chaperone function in the biogenesis of these pili and of bacterial attachment.
通过伴侣-分泌途径组装的细菌菌毛可通过特异性结合宿主组织中存在的糖类来介导微生物附着，这是感染发生的早期步骤。最近的研究开始揭示这些菌毛生物合成中伴侣功能以及细菌附着的结构基础。
