Bonner-Weir S
Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA.
Trends Endocrinol Metab. 2000 Nov;11(9):375-8. doi: 10.1016/s1043-2760(00)00305-2.
Pancreatic beta cells are responsible for maintaining the body's glucose levels within a very narrow range; their population is dynamic, with compensatory changes to maintain euglycemia. Throughout the lifetime of a mammal, low levels of beta-cell replication and apoptosis are balanced and result in a slowly increasing mass of beta cells. The emphasis in this review is on recent insights on the natural history of the beta cell in a normal pancreas: sources of renewal, survival and changes in differentiation.
胰腺β细胞负责将机体血糖水平维持在非常狭窄的范围内；其数量是动态变化的，会发生代偿性改变以维持血糖正常。在哺乳动物的整个生命周期中，β细胞的低水平复制和凋亡处于平衡状态，导致β细胞数量缓慢增加。本综述重点关注正常胰腺中β细胞自然史的最新见解：更新来源、存活情况以及分化变化。
