[卫星DNA与疾病——可能的机制。微卫星不稳定性]
[Satellite DNA and disease--possible mechanisms. Minisatellite instability].
作者信息
Patkin E L, Gaĭtskhoki V S
机构信息
Institute of Experimental Medicine, Russian Academy of Sciences, St. Petersburg, Russia.
出版信息
Genetika. 2000 Sep;36(9):1189-94.
PMID:11042804
Abstract
The main possible molecular mechanisms of minisatellite DNA instability are reviewed and compared with those of the trinucleotide repeat instability. Evidence indicating that some human diseases are associated with minisatellite DNA instability is presented including data on minisatellite DNA expansion.
摘要
本文综述了小卫星DNA不稳定性的主要潜在分子机制，并与三核苷酸重复序列不稳定性的机制进行了比较。文中还列举了一些表明人类疾病与小卫星DNA不稳定性相关的证据，包括小卫星DNA扩增的数据。
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