Golubeva M G, Grigor'eva M E
Biological Faculty, Moscow State University, Russia.
Izv Akad Nauk Ser Biol. 2000 Sep-Oct(5):631-5.
The effect of neurohypophysial hormones vasopressin and oxytocin as well as their synthetic analogs on platelet aggregation induced by thrombin or ADP was studied in vitro on washed rat platelets. Vasopressin and its analog DGAVP, as well as oxytocin enhanced thrombin-induced platelet aggregation, while their effect on ADP-induced aggregation was considerably lower. An oxytocin analog depotocin had a pronounced antithrombin effect indicated by a significant inhibition (by 81%) of thrombin-induced platelet aggregation and by assay for its antithrombin activity in the blood plasma.
在体外对洗涤过的大鼠血小板进行研究，以探讨神经垂体激素血管加压素和催产素及其合成类似物对凝血酶或二磷酸腺苷（ADP）诱导的血小板聚集的影响。血管加压素及其类似物去甘氨酸-精氨酸血管加压素（DGAVP）以及催产素可增强凝血酶诱导的血小板聚集，而它们对ADP诱导的聚集的影响则小得多。一种催产素类似物长效催产素具有显著的抗凝血酶作用，这表现为对凝血酶诱导的血小板聚集有显著抑制作用（81%），并且通过血浆中的抗凝血酶活性测定得以证实。
