Bernasconi A, Bernasconi N, Lassonde M, Toussaint P J, Meyer E, Reutens D C, Gotman J, Andermann F, Villemure J G
Montreal Neurological Hospital and Institute, Department of Neurology and Brain Imaging Center, McGill University, Quebec, Canada.
Neuroreport. 2000 Sep 28;11(14):3085-90. doi: 10.1097/00001756-200009280-00010.
To identify cortical structures that subserve residual motor and sensory function in patients with congenital hemiparesis due to a porencephalic cyst, we examined, using [(15)O]H2O, PET and somatosensory evoked potentials (SEPs) in three patients with left-sided hemiparesis who had undergone hemispherectomy. Motor stimulation of the affected hand produced ipsilateral activation in the premotor area in all patients, the SMA in two patients, and SII in two patients. Vibrotactile stimulation resulted in activation of the ipsilateral SII in all subjects. Median nerve stimulation of the affected hand produced ipsilateral long-latency SEPs in fronto-centro-parietal areas, whereas stimulation of the non-affected hand produced normal early cortical potentials in the contralateral hemisphere. Our results suggest that residual function in the paretic hand is warranted through non-primary motor and sensory areas, and higher order associative areas in the intact hemisphere.
为了确定因脑穿通畸形囊肿导致先天性偏瘫患者中维持残余运动和感觉功能的皮质结构，我们使用[（15）O]H2O、PET和体感诱发电位（SEP）对3例接受了大脑半球切除术的左侧偏瘫患者进行了检查。对患侧手进行运动刺激时，所有患者的运动前区均出现同侧激活，2例患者的辅助运动区出现激活，2例患者的第二躯体感觉区（SII）出现激活。振动触觉刺激在所有受试者中均导致同侧SII激活。对患侧手的正中神经进行刺激时，在额中央顶叶区域产生同侧长潜伏期SEP，而对未受影响的手进行刺激时，在对侧半球产生正常的早期皮质电位。我们的结果表明，瘫痪手的残余功能是通过完整半球中的非初级运动和感觉区域以及高级联合区域来维持的。
