Walker M P, Ayre G A, Perry E K, Wesnes K, McKeith I G, Tovee M, Edwardson J A, Ballard C G
MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne, UK.
Dement Geriatr Cogn Disord. 2000 Nov-Dec;11(6):327-35. doi: 10.1159/000017262.
Fluctuating cognition (FC) is a common and important symptom in dementia, particularly dementia with Lewy bodies (DLB), although it has not been empirically quantified or characterised. Forty subjects (15 DLB, 15 AD, 10 elderly controls) were evaluated using a clinical FC severity scale, as well as receiving measures of variability in attentional performance and slow EEG rhythms across 90 s, 1 h and 1 week. DLB patients had significantly more severe FC and more severe variability in attentional and slow electrocortical measures than either AD patients or normal controls in all time frames. Attentional and EEG variability also correlated significantly with independent clinical ratings of FC. Clinical quantification and measures of attention and EEG variability can therefore make an important and standardised contribution to the assessment of FC in dementia, facilitating future treatment studies with important implications for the potential causative mechanisms and differential diagnosis.
认知波动（FC）是痴呆症尤其是路易体痴呆（DLB）中常见且重要的症状，尽管尚未对其进行实证量化或特征描述。使用临床FC严重程度量表对40名受试者（15名DLB患者、15名阿尔茨海默病（AD）患者、10名老年对照者）进行了评估，并在90秒、1小时和1周内对注意力表现的变异性和慢脑电节律进行了测量。在所有时间范围内，DLB患者的FC严重程度明显更高，注意力和慢皮层电活动测量的变异性也比AD患者或正常对照者更严重。注意力和脑电图变异性也与FC的独立临床评分显著相关。因此，临床量化以及注意力和脑电图变异性测量可为痴呆症中FC的评估做出重要且标准化的贡献，有助于未来的治疗研究，对潜在病因机制和鉴别诊断具有重要意义。
