Francès C, el-Rassi R, Piette J C
Service de Médecine interne, Hôpital de la Pitié, Paris.
Presse Med. 2000 Sep 23;29(27):1520-4.
Dermatological manifestations are frequently observed in patients with relapsing polychondritis. However, they have not been extensively studied as polychondritis is a rare disease and the reported dermatological manifestations appear to be nonspecific. A WIDE SPECTRUM: The most frequently observed manifestations are aphthosis with sometimes complex aphthosis, nodular papular or purpuric lesions. Neutrophilic dermatosis has been reported in isolated cases. Histologically, these lesions correspond to nonspecific inflammatory infiltrates, vasculitis or thrombosis. Various pathological findings are observed in nodular lesions. RELATED AND OVERLAP CONDITIONS: Similar dermatological manifestations occur in Behçet's syndrome and in inflammatory bowel diseases. Patients with relapsing polychondritis and myelodysplasia very frequently have dermatological manifestations. Repeated blood cell determinations are therefore necessary in patients with relapsing polychondritis and dermatological manifestations.
复发性多软骨炎患者常出现皮肤表现。然而，由于多软骨炎是一种罕见疾病，且所报道的皮肤表现似乎不具有特异性，因此尚未对其进行广泛研究。
最常观察到的表现是口疮，有时是复杂口疮、结节性丘疹或紫癜性病变。孤立病例中曾报道过嗜中性皮病。组织学上，这些病变对应于非特异性炎症浸润、血管炎或血栓形成。在结节性病变中观察到各种病理表现。
白塞病和炎症性肠病中也会出现类似的皮肤表现。复发性多软骨炎和骨髓发育异常患者也常出现皮肤表现。因此，对于有皮肤表现的复发性多软骨炎患者，需要反复进行血细胞测定。
