Soska V
Fakultní nemocnice u svaté Anny v Brnĕ, Brno.
Vnitr Lek. 1999 Jul;45(7):441-3.
LDL-cholesterol subfractions have a different atherogenity; the most atherogenic are small LDL3 called small dense LDL. A clear relationship was proved between their concentration and early manifestation of ischaemic heart disease. In some instances they were found to act as an independent risk factor of cardiovascular disease. Their concentration depends to a great extent on the triacyglycerol concentration. They are found most frequently in patients with combined hyperlipidaemia, in associated metabolic syndrome and in patients with type 2 diabetes mellitus. Their plasma concentration can be reduced by non-pharmacological methods (restriction of animal fats, reduction of body weight, physical activity) as well as by pharmacological means (in particular fibrates). Micronized phenofibrate reduces significantly the concentration of small LDL3 and thus contributes to normalization of dyslipoproteinaemia and reduction of the risk of cardiovascular complications.
低密度脂蛋白胆固醇亚组分具有不同的致动脉粥样硬化性；最具致动脉粥样硬化性的是称为小而密低密度脂蛋白的小LDL3。已证实它们的浓度与缺血性心脏病的早期表现之间存在明确的关系。在某些情况下，它们被发现是心血管疾病的独立危险因素。它们的浓度在很大程度上取决于甘油三酯浓度。它们最常见于合并高脂血症患者、相关代谢综合征患者和2型糖尿病患者。它们的血浆浓度可以通过非药物方法（限制动物脂肪、减轻体重、体育活动）以及药物手段（特别是贝特类药物）降低。微粒化非诺贝特可显著降低小LDL3的浓度，从而有助于血脂蛋白异常的正常化并降低心血管并发症的风险。
