在1-四氢萘酮的烯醇锂盐与活性卤代烃的烷基化反应中，单烷基化产物与二烷基化产物的比例较高时的速率增强。
Rate enhancement with high ratio of the monoalkylated product to the dialkylated product in the alkylation of the lithium enolate of 1-tetralone with reactive alkyl halides.
作者信息
Goto M, Akimoto K, Aoki K, Shindo M, Koga K
机构信息
Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2000 Oct;48(10):1529-31. doi: 10.1248/cpb.48.1529.
PMID:11045463
Abstract
The reactions of the lithium enolate of 1-tetralone with reactive alkyl halides were examined in the absence and in the presence of 3 eq of various ligands for the lithium. It is shown that the rates of the reactions are enhanced greatly in the presence a tetradentate amine (1,1,4,7,10,10-hexamethyltriethylenetetramine), and the ratio of the monoalkylated product to the dialkylated product is increased under shorter reaction times.
摘要
在不存在和存在3当量各种锂配体的情况下，研究了1-四氢萘酮的烯醇锂与活性卤代烃的反应。结果表明，在四齿胺（1,1,4,7,10,10-六甲基三亚乙基四胺）存在下，反应速率大大提高，并且在较短反应时间下单烷基化产物与二烷基化产物的比例增加。
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