Laposata M, Kabakibi A, Walden M P, Cluette-Brown J E, Nanji A A, Refaai M A, Werner J, Nanji A A
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA.
Alcohol Clin Exp Res. 2000 Oct;24(10):1488-91.
Fatty acid ethyl esters (FAEE) are nonoxidative ethanol metabolites that have been shown to be long term markers of ethanol intake and have been implicated as mediators of ethanol-induced cell injury. Previous studies have indicated that the fatty acid composition of the FAEE found in the plasma of human subjects after ethanol ingestion is predominantly ethyl palmitate and ethyl oleate. This raised the possibility that there is some selectivity toward the fatty acid used for FAEE to be exported from the liver into the blood.
To address the hypothesis that the fatty acid composition of FAEE secreted from organs, such as the liver and pancreas, differs from the fatty acid composition of FAEE in the organs, this study was performed using rats that received ethanol by intra-arterial infusion.
It was found that the fatty acids in FAEE differed significantly in plasma versus liver, bile versus liver, and pancreatic secretions versus pancreas.
These results indicate that organs selectively export certain FAEE species.
脂肪酸乙酯（FAEE）是乙醇的非氧化代谢产物，已被证明是乙醇摄入量的长期标志物，并被认为是乙醇诱导细胞损伤的介质。先前的研究表明，人类受试者摄入乙醇后血浆中发现的FAEE的脂肪酸组成主要是棕榈酸乙酯和油酸乙酯。这就提出了一种可能性，即从肝脏输出到血液中的用于合成FAEE的脂肪酸存在某种选择性。
为了验证从肝脏和胰腺等器官分泌的FAEE的脂肪酸组成与器官内FAEE的脂肪酸组成不同这一假设，本研究使用通过动脉内输注给予乙醇的大鼠进行。
发现血浆与肝脏、胆汁与肝脏以及胰腺分泌物与胰腺中的FAEE中的脂肪酸存在显著差异。
这些结果表明器官选择性地输出某些FAEE种类。
