Chromatographic resolution of enantiomers selective review.

Recent research has produced a notable increase in knowledge useful for chromatographic enantiomer resolution. Some major advances have emerged in the understanding of asymmetric solute-solvent interactions, and many successful separations by gas and by liquid chromatography have been reported. This review presents a selective discussion of the major advances, with primary emphasis on the use of chiral stationary phases. The latter offer advantages (over indirect techniques) such as generally easier sample preparation, decreased analysis time, and simultaneous chemical as well as optical purity analysis.