Dreux C, Launay J M, Laplanche J L
Bull Mem Acad R Med Belg. 2000;155(1-2):99-108; discussion 108-11.
The transmissible spongiform encephalopathies (TSEs) or "prions diseases", provokes some controversies about their origins and possible transmission from animals to humans. Important advances were obtained recently on the genetical TSEs with the genotypic diagnosis methods based on the discovery of numerous mutations and inclusions in the PRNP gene coding for prion protein. The possible connection between the bovine spongiform encephalopathy (BSE) and the newvariant of Creutzfeldt-Jakob disease (nv-CJD) ask numerous questions in terms of public health. Lastly, the important problem of biological diagnosis of "prions diseases" presents interesting advances that must be continued and supported by the public health authorities.
传染性海绵状脑病（TSEs）或“朊病毒疾病”，引发了关于其起源以及从动物传播给人类可能性的一些争议。最近，基于在编码朊病毒蛋白的PRNP基因中发现众多突变和内含子的基因分型诊断方法，在遗传性TSEs方面取得了重要进展。牛海绵状脑病（BSE）与新型克雅氏病（nv-CJD）之间的可能联系在公共卫生方面引发了诸多问题。最后，“朊病毒疾病”的生物学诊断这一重要问题呈现出了一些有趣的进展，必须由公共卫生当局继续推进并提供支持。
