Kucinský R, Gonsorcík J, Franko J, Rajnic A, Olexa P
IV. interná klinika FN L. Pasteura LF UPJS, Kosice.
Vnitr Lek. 2000 Feb;46(2):130-5.
Signal-averaged electrocardiography of the QRS complex detects presence of late potentials which represent significant arrhythmogenic marker responsible for increased risk of life-threatening ventricular arrhythmias especially in post myocardial infarction patients. The P wave signal-averaged electrocardiography has been designed to predict development of atrial fibrillation in different populations of patients. Many P wave signal-averaging methodological procedures have been developed. However their common disadvantages remain lack of standardization, relatively low specificity and sensitivity, low positive predictive value as well as limited number of larger prospective clinical trials. Recent software and technological improvements of the P wave high resolution techniques as well as some new reports about the influence of antiarrhythmic drugs on the parameters of the P wave signal-averaged electrocardiography are creating new possibilities not only for the diagnosis of paroxysmal atrial fibrillation but also for the prediction of antiarrhythmic drug efficiency.
QRS 复合波的信号平均心电图可检测到晚期电位的存在，晚期电位是重要的致心律失常标志物，会增加危及生命的室性心律失常风险，尤其是在心肌梗死患者中。P 波信号平均心电图旨在预测不同患者群体中房颤的发生。已经开发了许多 P 波信号平均的方法程序。然而，它们的共同缺点仍然是缺乏标准化、特异性和敏感性相对较低、阳性预测值低以及大型前瞻性临床试验数量有限。P 波高分辨率技术的最新软件和技术改进以及关于抗心律失常药物对 P 波信号平均心电图参数影响的一些新报告，不仅为阵发性房颤的诊断，也为抗心律失常药物疗效的预测创造了新的可能性。
