Hayden J M, Reaven P D
Department of Medicine, Carl T. Hayden Veterans Administration Medical Center, Phoenix, Arizona 85012-1892, USA.
Curr Opin Lipidol. 2000 Oct;11(5):519-28. doi: 10.1097/00041433-200010000-00010.
A major consequence of diabetes mellitus type 2 is the accelerated development of atherosclerosis. Assessment of conventional risk factors such as plasma lipids, lipoproteins and hypertension only partly account for the excessive risk of developing cardiovascular disease in this population. Increasing evidence has emerged suggesting that conditions associated with diabetes mellitus type 2, such as insulin resistance, hyperinsulinemia and hyperglycemia, may also play a significant role in regulating 'novel' cardiovascular risk factors. These factors and their potential roles in the development of atherosclerosis and cardiovascular events are discussed in this review.
2型糖尿病的一个主要后果是动脉粥样硬化的加速发展。对传统风险因素如血脂、脂蛋白和高血压的评估仅部分解释了该人群发生心血管疾病的过高风险。越来越多的证据表明，与2型糖尿病相关的状况，如胰岛素抵抗、高胰岛素血症和高血糖，可能在调节“新型”心血管风险因素方面也发挥着重要作用。本综述将讨论这些因素及其在动脉粥样硬化和心血管事件发生发展中的潜在作用。
