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Responses of Clostridium botulinum type B and E progenitor toxins to some clostridial sulfhydryl-dependent proteases.

作者信息

Oishi I, Okada T, Sakaguchi G

出版信息

Jpn J Med Sci Biol. 1975 Jun;28(3):157-64. doi: 10.7883/yoken1952.28.157.

DOI:10.7883/yoken1952.28.157
PMID:1104932
Abstract

Sulfhydryl-dependent proteases produced by Clostridium botulinum types A, B, and F, Clostridium histolyticum, Clostridium sporogenes and Clostridium perfringens activate preferentially type E over type B progenitor toxin but less efficiently than trypsin. The results explain why activable toxin is demonstrable in culture of a strongly proteolytic type B strain.

摘要

相似文献

1
Responses of Clostridium botulinum type B and E progenitor toxins to some clostridial sulfhydryl-dependent proteases.
Jpn J Med Sci Biol. 1975 Jun;28(3):157-64. doi: 10.7883/yoken1952.28.157.
2
Response of type B and E Botulinum toxins to purified sulfhydryl-dependent protease produced by Clostridium botulinum type F.
Jpn J Med Sci Biol. 1977 Aug;30(4):179-90. doi: 10.7883/yoken1952.30.179.
3
Proteases produced by a proteolytic mutant of Clostridium botulinum type E.
J Gen Microbiol. 1978 Jul;107(1):85-91. doi: 10.1099/00221287-107-1-85.
4
Role of a protease in natural activation of Clostridium botulinum neurotoxin.一种蛋白酶在肉毒梭菌神经毒素天然激活中的作用。
Infect Immun. 1972 Oct;6(4):587-90. doi: 10.1128/iai.6.4.587-590.1972.
5
Divergency of nicking of the toxin from the proteolytic activity of Clostridium botulinum of different types.
Jpn J Med Sci Biol. 1979 Apr;32(2):130-2.
6
Activation of Clostridium botulinum type B toxin by an endogenous enzyme.内源性酶对B型肉毒梭菌毒素的激活作用。
J Bacteriol. 1971 Dec;108(3):1051-7. doi: 10.1128/jb.108.3.1051-1057.1971.
7
Proteases of Clostridium botulinum. VI. The role of trypsin, Clostridium botulinum proteases and protease inhibitors in the formation and activation of toxin in growing cultures of Clostridium botulinum.肉毒梭菌蛋白酶。VI. 胰蛋白酶、肉毒梭菌蛋白酶及蛋白酶抑制剂在肉毒梭菌生长培养物中毒素形成与激活过程中的作用
Acta Vet Scand. 1974;15(4):487-506. doi: 10.1186/BF03547221.
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Nicking of single chain Clostridium botulinum type A neurotoxin by an endogenous protease.
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9
Activation of botulinum toxins in the absence of nicking.
Infect Immun. 1977 Aug;17(2):402-7. doi: 10.1128/iai.17.2.402-407.1977.
10
Antigenic relationships among the proteolytic and nonproteolytic strains of Clostridium botulinum.肉毒梭菌的蛋白水解型菌株与非蛋白水解型菌株之间的抗原关系。
Appl Microbiol. 1971 Feb;21(2):295-9. doi: 10.1128/am.21.2.295-299.1971.

引用本文的文献

1
Clostridium botulinum neurotoxin.肉毒梭菌神经毒素
Microbiol Rev. 1980 Sep;44(3):419-48. doi: 10.1128/mr.44.3.419-448.1980.
2
Purification and characterization of a protease from Clostridium botulinum type A that nicks single-chain type A botulinum neurotoxin into the di-chain form.
J Bacteriol. 1990 May;172(5):2498-503. doi: 10.1128/jb.172.5.2498-2503.1990.
3
Proteolytic mutants obtained from Clostridium botulinum type E.从E型肉毒梭菌获得的蛋白水解突变体。
Appl Environ Microbiol. 1977 Jul;34(1):99-101. doi: 10.1128/aem.34.1.99-101.1977.
4
Effect of zinc and calcium ions on the production of alpha-toxin and proteases by Clostridium perfringens.锌离子和钙离子对产气荚膜梭菌产生α毒素和蛋白酶的影响。
Infect Immun. 1978 May;20(2):325-33. doi: 10.1128/iai.20.2.325-333.1978.