Oppolzer R, Schieler K, Leithner C, Pinggera W, Wolf A, Stummvoll H, Singer F
Klin Wochenschr. 1975 Sep 1;53(17):803-8. doi: 10.1007/BF01466751.
In the first three weeks after kidney transplantation the patients were examined for daily changes in immunoglobulin levels. Only very seldom was a decrease of IgM detected in our patients who had undergone splenectomy. During half of the rejection crisis there were indeed short periods of increase (spikes) in immunoglobulins. These were observed always before or concomitantly with the clinical diagnosis of a rejection reaction. In order to determine the connection between immunoglobulin-spikes and an approaching rejection episode the general one-sided binominal test was used. A significant relation was established between IgM peaks and an approaching rejection crisis. No such relation could be found for the IgA peaks observed. The IgG globulins showed no consistent pattern during a transplantation rejection. A persistent fall of the IgG globulins was noted in the first ten days after renal allograft with the immunosuppressive regimen of an initial gramme of methylprednisolon and high dosage of azothioprine. A good correlation was observed with the simultaneous depression of serum albumin concentrations. As losses of protein in urine are minimal (already confirmed by other authors), it must be assumed that in the first place a high rate of catabolism and a restriction in the protein synthesis is responsible for the decrease in the IgG globulins and the serum albumins.
在肾移植后的前三周，对患者进行免疫球蛋白水平每日变化的检查。在我们接受脾切除术的患者中，仅极罕见地检测到IgM降低。在一半的排斥反应期，免疫球蛋白确实有短时间升高（峰值）。这些总是在排斥反应临床诊断之前或同时观察到。为了确定免疫球蛋白峰值与即将发生的排斥反应之间的联系，使用了一般单侧二项式检验。在IgM峰值与即将发生的排斥反应期之间建立了显著关系。对于观察到的IgA峰值，未发现这种关系。在移植排斥期间，IgG球蛋白没有一致的模式。在肾移植后的前十天，采用首剂1克甲基强的松龙和高剂量硫唑嘌呤的免疫抑制方案时，观察到IgG球蛋白持续下降。同时观察到与血清白蛋白浓度降低有良好相关性。由于尿中蛋白质损失极少（其他作者已证实），必须首先假定高分解代谢率和蛋白质合成受限是导致IgG球蛋白和血清白蛋白降低的原因。
