Levy J, Barnett E V, MacDonald N S, Klinenberg J R, Pearson C M
J Clin Invest. 1972 Sep;51(9):2233-8. doi: 10.1172/JCI107031.
The effect of azathioprine therapy on gammaglobulin synthesis was evaluated in nine patients with rheumatic disorders. The rates of synthesis of IgG and IgM were calculated before and after 4 months of azathioprine treatment using turnover studies of radioiodinated gammaglobulins. The synthesis of IgG decreased 33.4% of the initial IgG synthetic rate. Seven of nine patients showed reductions of IgG synthesis ranging from 16.8 to 74.1%. IgM production decreased from 24.5 to 74.2% in eight of nine patients with a mean reduction of 40.9%. Studies before and after a control period of 4 months of placebo in six patients revealed a mean increase in IgG and IgM synthesis. Serum immunoglobulin concentrations after 4 months of azathioprine treatment were not consistently reduced and did not parallel changes in immunoglobulin synthesis. Reduced gammaglobulin synthesis may play a role in the therapeutic action of this and other "immunosuppressive" drugs.
在9例风湿性疾病患者中评估了硫唑嘌呤治疗对γ球蛋白合成的影响。使用放射性碘化γ球蛋白的周转率研究，计算了硫唑嘌呤治疗4个月前后IgG和IgM的合成率。IgG的合成下降至初始IgG合成率的33.4%。9例患者中有7例IgG合成减少，幅度为16.8%至74.1%。9例患者中有8例IgM产生从24.5%降至74.2%，平均下降40.9%。6例患者在4个月安慰剂对照期前后的研究显示，IgG和IgM合成平均增加。硫唑嘌呤治疗4个月后的血清免疫球蛋白浓度并未持续降低，也与免疫球蛋白合成的变化不一致。γ球蛋白合成减少可能在该药物及其他“免疫抑制”药物的治疗作用中发挥作用。
