Gray Y H
Molecular Genetics and Evolution Group, Research School of Biological Sciences, Australian National University, ACT 2601, Canberra, Australia.
Trends Genet. 2000 Oct;16(10):461-8. doi: 10.1016/s0168-9525(00)02104-1.
Transposable elements (TEs) promote various chromosomal rearrangements more efficiently, and often more specifically, than other cellular processes(1-3). One explanation of such events is homologous recombination between multiple copies of a TE present in a genome. Although this does occur, strong evidence from a number of TE systems in bacteria, plants and animals suggests that another mechanism - alternative transposition - induces a large proportion of TE-associated chromosomal rearrangements. This paper reviews evidence for alternative transposition from a number of unrelated but structurally similar TEs. The similarities between alternative transposition and V(D)J recombination are also discussed, as is the use of alternative transposition as a genetic tool.
转座元件（TEs）比其他细胞过程更有效地促进各种染色体重排，而且往往更具特异性(1-3)。对此类事件的一种解释是基因组中存在的TE的多个拷贝之间的同源重组。虽然这种情况确实会发生，但来自细菌、植物和动物中许多TE系统的有力证据表明，另一种机制——替代转座——会诱导很大一部分与TE相关的染色体重排。本文综述了来自一些不相关但结构相似的TEs的替代转座证据。还讨论了替代转座与V(D)J重组之间的相似性，以及替代转座作为一种遗传工具的用途。
