Shenefelt R E
Methods Achiev Exp Pathol. 1975;7:1-21.
Traditional approaches to human and experimental teratology are briefly described, with roles of pathologists indicated. Some approaches to experimental teratology which pathologists might use are then described and illustrated. These include identification of subclasses of malformation types, study of the chronologic sequence of maldevelopment, study of embryo death, and examination of tumor-malformation relationships. The malformations used to illustrate these approaches are cleft palate, anencephaly, hydrocephalus, and intestinal atresia. The final section deals with general methodology in experimental teratology; a listing of books dealing with experimental teratology is included.
本文简要描述了人类和实验性致畸学的传统方法，并指出了病理学家的作用。然后描述并举例说明了病理学家可能采用的一些实验性致畸学方法。这些方法包括畸形类型子类别的识别、发育异常时间顺序的研究、胚胎死亡的研究以及肿瘤与畸形关系的检查。用于说明这些方法的畸形包括腭裂、无脑儿、脑积水和肠闭锁。最后一部分讨论了实验性致畸学的一般方法；其中还列出了有关实验性致畸学的书籍。
