Mognato G, Cecchetto G, Carli M, Talenti E, d'Amore E S, Pederzini F, Guglielmi M
Department of Pediatrics, University of Padua, Italy.
J Pediatr Surg. 2000 Oct;35(10):1511-3. doi: 10.1053/jpsu.2000.16428.
Lipoblastoma is an uncommon, benign mesenchymal tumor with an excellent prognosis despite its potential to local invasion and rapid growth. However, in the literature, a spontaneous resolution has never been reported, and, consequently, the need for a complete surgical excision has never been questioned. The authors report a case of a 2-day-old boy with congenital diffuse lipoblastoma in the left thigh, which forced us to withhold from surgical treatment to avoid the risk of mutilation in a patient so young. The lesion was followed-up by imaging, and a complete spontaneous resolution of the diffuse lipoblastoma was shown by magnetic resonance imaging (MRI) at 1-year follow-up. In the literature, a complete surgical excision is recommended. The results of this case suggest that a "wait and see" approach is justified at least in infants with huge invasive lesions requiring a mutilating excision.
脂肪母细胞瘤是一种罕见的良性间叶组织肿瘤，尽管它有局部侵袭和快速生长的可能，但预后良好。然而，在文献中，从未有过自发消退的报道，因此，完全手术切除的必要性从未受到质疑。作者报告了一例2日龄男婴，其左大腿患有先天性弥漫性脂肪母细胞瘤，鉴于患儿年龄过小，为避免致残风险，我们未对其进行手术治疗。通过影像学对该病变进行随访，在1年的随访中，磁共振成像（MRI）显示弥漫性脂肪母细胞瘤完全自发消退。文献中推荐进行完全手术切除。该病例结果表明，至少对于患有巨大侵袭性病变且需要进行致残性切除的婴儿，“观察等待”的方法是合理的。
