Janion C
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa.
Acta Biochim Pol. 2000;47(2):451-7.
This is a short survey of the adaptive mutation processes that arise in non- or slowly-dividing bacterial cells and includes: (i) bacterial models in which adaptive mutations are studied; (ii) the mutagenic lesions from which these mutations derive; (iii) the influence of DNA repair processes on the spectrum of adaptive mutations. It is proposed that in starved cells, likely as during the MFD phenomenon, lesions in tRNA suppressor genes are preferentially repaired and no suppressor tRNAs are formed as a result of adaptive mutations. Perhaps the most provocative proposal is (iv) a hypothesis that the majority of adaptive mutations are selected in a pre-apoptotic state where the cells are either mutated, selected, and survive, or they die.
这是一篇关于在非分裂或缓慢分裂细菌细胞中出现的适应性突变过程的简短综述，内容包括：（i）研究适应性突变的细菌模型；（ii）这些突变所源自的诱变损伤；（iii）DNA修复过程对适应性突变谱的影响。有人提出，在饥饿细胞中，可能如同在MFD现象期间一样，tRNA抑制基因中的损伤会被优先修复，并且适应性突变不会产生抑制性tRNA。或许最具启发性的提议是（iv）一个假说，即大多数适应性突变是在细胞处于预凋亡状态时被选择的，此时细胞要么发生突变、被选择并存活下来，要么死亡。
