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对强化胰岛素治疗下未达到治疗目标的1型糖尿病患者进行整体治疗和教学计划的评估。

Evaluation of a holistic treatment and teaching programme for patients with Type 1 diabetes who failed to achieve their therapeutic goals under intensified insulin therapy.

作者信息

Bott U, Bott S, Hemmann D, Berger M

机构信息

Department of Nutrition and Metabolic Diseases (WHO-Collaborating Center for Diabetes), Heinrich-Heine-University, Düsseldorf, Germany.

出版信息

Diabet Med. 2000 Sep;17(9):635-43. doi: 10.1046/j.1464-5491.2000.00345.x.

Abstract

AIMS

To evaluate a treatment and teaching programme including psychosocial modules for patients with Type 1 diabetes mellitus on intensified insulin therapy who failed to achieve their treatment goals despite participation in standard programmes.

METHODS

The 5-day inpatient programme comprises small groups of 4-6 patients, focusing on individual needs and problems. Beyond the teaching lessons (most topics are deliberately chosen by the patients), the programme provides intensive group discussions and offers individual counselling concerning motivational aspects, psychosocial problems and coping strategies. Of the first consecutive 83 participants, 76 were re-examined after 17.5 +/- 5.5 months (range 9-31 months).

RESULTS

At follow-up, HbA1c was not improved compared to baseline (8.0 +/- 1.3% vs. 8.1 +/- 1.5%). However, the incidence of severe hypoglycaemia per patient/year (glucose i.v., glucagon injection) was substantially decreased: 0.62 +/- 1.5 episodes at baseline compared to 0.16 +/- 0.9 at follow-up (P < 0.001). Twenty-six per cent of the patients at baseline, and 4% at re-examination had experienced at least one episode of severe hypoglycaemia during the preceding year (P < 0.001). Sick leave days per patient/year decreased from 17.0 +/- 38.5-7.7 +/- 13.6 days (P < 0.05). Patients improved their perceptions of self-efficacy, their relationship to doctors and felt less externally controlled (P < 0.001). The majority of patients perceived an improved competence regarding diet (80.6%) and adaptation of insulin dosage (82.4%), an improved knowledge (82.2%), and a renewed motivation for the treatment (84.5%). Treatment success was significantly associated with baseline HbA1c, stability of motivation, frequency of blood glucose self-monitoring, control beliefs and change in subsequent outpatient care.

CONCLUSIONS

The programme improved glycaemic control mainly as a result of a substantial reduction in the incidence of severe hypoglycaemia. Patients with persistent poor glycaemic control may benefit from structured follow-up care focusing on motivational aspects of self-management and psychosocial support.

摘要

目的

评估一项针对强化胰岛素治疗但尽管参与标准项目仍未达到治疗目标的1型糖尿病患者的治疗与教学项目,该项目包括心理社会模块。

方法

为期5天的住院项目以4至6名患者的小组为单位,关注个体需求和问题。除教学课程(大多数主题由患者自行选择)外,该项目还提供深入的小组讨论,并就动机方面、心理社会问题及应对策略提供个体咨询。在首批连续的83名参与者中,76人在17.5±5.5个月(9至31个月)后接受了复查。

结果

随访时,糖化血红蛋白(HbA1c)与基线相比无改善(8.0±1.3%对8.1±1.5%)。然而,每位患者每年严重低血糖的发生率(静脉注射葡萄糖、注射胰高血糖素)大幅下降:基线时为0.62±1.5次发作,随访时为0.16±0.9次发作(P<0.001)。基线时26%的患者以及复查时4%的患者在前一年至少经历过一次严重低血糖发作(P<0.001)。每位患者每年的病假天数从17.0±38.5天降至7.7±13.6天(P<0.05)。患者对自我效能的认知、与医生的关系得到改善,感觉外部控制减少(P<0.001)。大多数患者认为在饮食(80.6%)和胰岛素剂量调整(82.4%)方面的能力有所提高,知识有所增加(82.2%),并且对治疗有了新的动力(84.5%)。治疗成功与基线HbA1c、动机稳定性、血糖自我监测频率、控制信念以及后续门诊护理的变化显著相关。

结论

该项目主要通过大幅降低严重低血糖的发生率改善了血糖控制。血糖控制持续不佳的患者可能受益于以自我管理的动机方面和心理社会支持为重点的结构化随访护理。

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