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在住院和门诊环境中,对接受常规胰岛素治疗的 2 型糖尿病患者进行治疗和教育计划后,HbA1c 显著改善。

Substantial improvement in HbA1c following a treatment and teaching programme for people with type 2 diabetes on conventional insulin therapy in an in- and outpatient setting.

机构信息

Endocrinology and Metabolic Diseases, Department of Internal Medicine III, Jena University Hospital, Am Klinikum 1, 07740, Jena, Germany.

Diabetes Center Thuringia (Diabeteszentrum Thüringen e.V.), Jena, Germany.

出版信息

Acta Diabetol. 2018 Feb;55(2):131-137. doi: 10.1007/s00592-017-1070-2. Epub 2017 Nov 17.

Abstract

AIMS

The aim of the study was to assess the efficacy of a patient education programme (DTTP) for the optimisation of conventional insulin therapy in patients with type 2 diabetes in an in- and outpatient setting.

METHODS

The study was designed as a prospective, longitudinal trial. Thirty-three people with diabetes (females 54.5%, age 61.0 years, diabetes duration 12.7 years, HbA1c 9.3%) from ten general practices in Thuringia (outpatient group) participated in a DTTP for conventional insulin therapy. Thirty-three individuals-matched pairs-(female 72.7%, age 63.2 years, diabetes duration 13.6 years, HbA1c 9.7%) who were hospitalised for the optimisation of conventional insulin therapy participated in the same DTTP during their hospitalisation. All individuals were invited to participate in an outpatient follow-up visit 12 months after participation in the DTTP.

RESULTS

All participants were re-examined after 1.0 ± 0.2 years. HbA1c improved in both groups equally by 1.2% in the outpatient group and 1.3% in the inpatient group. Insulin dosage increased marginally within the outpatient group (+ 0.09 units/kg/day, p = 0.023) and remained stable within the inpatients. Blood glucose self-monitoring increased significantly in both groups without inter-group difference (+ 7.9 vs. + 6.4 tests per week).

CONCLUSION

Participation in an out- or inpatient DTTP improved substantially HbA1c levels in people with type 2 diabetes on conventional insulin treatment. Probably, the improved adjustment of the eating behaviour to the insulin therapy was the reason for improved metabolic control. Guidelines should recommend "refresher" programmes when metabolic control deteriorates before an intensification of blood glucose-lowering treatment.

摘要

目的

本研究旨在评估患者教育计划(DTTP)在门诊和住院环境中优化 2 型糖尿病患者常规胰岛素治疗的疗效。

方法

该研究设计为前瞻性、纵向试验。来自图林根州的十家全科诊所的 33 名糖尿病患者(女性占 54.5%,年龄 61.0 岁,糖尿病病程 12.7 年,HbA1c9.3%)参与了常规胰岛素治疗的 DTTP。33 名患者(匹配对,女性占 72.7%,年龄 63.2 岁,糖尿病病程 13.6 年,HbA1c9.7%)因常规胰岛素治疗优化住院,他们在住院期间接受了相同的 DTTP。所有参与者均被邀请在参与 DTTP 后 12 个月进行门诊随访。

结果

所有参与者在 1.0±0.2 年后均再次接受检查。门诊组的 HbA1c 平均降低 1.2%,住院组降低 1.3%,两组患者的 HbA1c 均得到同样改善。门诊组的胰岛素剂量略有增加(+0.09 单位/千克/天,p=0.023),住院组保持稳定。两组患者的自我血糖监测均显著增加,两组间无差异(每周增加 7.9 次与 6.4 次)。

结论

参与门诊或住院 DTTP 可显著改善接受常规胰岛素治疗的 2 型糖尿病患者的 HbA1c 水平。可能是由于饮食行为对胰岛素治疗的调整改善了代谢控制。当血糖降低治疗强化前代谢控制恶化时,指南应推荐“更新”方案。

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