Stötter L, Fischer M, Stock M, Braveny I, Hägele U, Grünberg G, Schulze H P
Nephron. 1975;15(6):444-55. doi: 10.1159/000180528.
Chronic pyelonephritis, especially that caused by the most common invader E. coli, corresponding satisfactorily to the pathophysiology of the human disease is difficult to reproduce. We have developed a pattern of infection with which we succeeded reliably in producing a chronic E. coli pyelonephritis. This was achieved by inserting a plastic catheter into the renal pelvis. A suspension of E. coli was injected via the catheter into the renal pelvis of 32 rabbits. This pattern of infection takes a chronic progressive course and, in all cases, results in typical macroscopic and histological changes in the kidney. The bacterial excretion in the urine remains unchanged over a period of months. With the experimental procedure described, the pathogenesis and pathophysiology of chronic E. coli pyelonephritis can be clearly studied. Drugs currently used on patients can be tested for their effectiveness in long-term application.
慢性肾盂肾炎，尤其是由最常见的病原体大肠杆菌引起的慢性肾盂肾炎，很难按照人类疾病的病理生理学特征令人满意地复制出来。我们已经开发出一种感染模式，通过这种模式我们成功地可靠诱导出慢性大肠杆菌肾盂肾炎。这是通过将一根塑料导管插入肾盂来实现的。将大肠杆菌悬液通过导管注入32只兔子的肾盂。这种感染模式呈慢性进行性病程，并且在所有病例中，都会导致肾脏出现典型的宏观和组织学变化。尿液中的细菌排放在数月内保持不变。通过所描述的实验方法，可以清楚地研究慢性大肠杆菌肾盂肾炎的发病机制和病理生理学。目前用于患者的药物可以进行长期应用有效性测试。
