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[高脂血症的当前饮食及药物治疗]

[Current dietetic and pharmacological treatment of hyperlipoproteinemia].

作者信息

Caruzzo C

出版信息

Minerva Med. 1975 Dec 8;66(84):4527-34.

PMID:1105243
Abstract

Secondary hyperlipoproteinaemia necessitates direct management of the main disease (hypothyroidism, nephrosis, etc.), whereas primary forms are essentially handled by dietary regimens adapted to subject types, as classified by Fredrickson-Levy-Lees and adopted by the WHO. These regimens are described and discussed schematically. Drugs may be employed if diet proves ineffectual. Anionic exchange resins, d-thyroxine, clofibrate and nicotinic acid have been shown effective for this purpose. Their mechanisms, doses and side-effects are described. The criteria governing their selection are explained in the light of the recent literature and with reference to the six phenotypes proposed by Fredrickson-Levy-Lees.

摘要

继发性高脂蛋白血症需要对主要疾病(甲状腺功能减退、肾病等)进行直接治疗,而原发性形式主要通过根据弗雷德里克森 - 利维 - 李斯分类并被世界卫生组织采用的适合个体类型的饮食方案来处理。这些方案将进行简要描述和讨论。如果饮食治疗无效,可以使用药物。阴离子交换树脂、d - 甲状腺素、氯贝丁酯和烟酸已被证明对此有效。文中描述了它们的作用机制、剂量和副作用。根据近期文献并参考弗雷德里克森 - 利维 - 李斯提出的六种表型,解释了选择这些药物的标准。

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