Caruzzo C
Minerva Med. 1975 Dec 8;66(84):4527-34.
Secondary hyperlipoproteinaemia necessitates direct management of the main disease (hypothyroidism, nephrosis, etc.), whereas primary forms are essentially handled by dietary regimens adapted to subject types, as classified by Fredrickson-Levy-Lees and adopted by the WHO. These regimens are described and discussed schematically. Drugs may be employed if diet proves ineffectual. Anionic exchange resins, d-thyroxine, clofibrate and nicotinic acid have been shown effective for this purpose. Their mechanisms, doses and side-effects are described. The criteria governing their selection are explained in the light of the recent literature and with reference to the six phenotypes proposed by Fredrickson-Levy-Lees.
继发性高脂蛋白血症需要对主要疾病(甲状腺功能减退、肾病等)进行直接治疗,而原发性形式主要通过根据弗雷德里克森 - 利维 - 李斯分类并被世界卫生组织采用的适合个体类型的饮食方案来处理。这些方案将进行简要描述和讨论。如果饮食治疗无效,可以使用药物。阴离子交换树脂、d - 甲状腺素、氯贝丁酯和烟酸已被证明对此有效。文中描述了它们的作用机制、剂量和副作用。根据近期文献并参考弗雷德里克森 - 利维 - 李斯提出的六种表型,解释了选择这些药物的标准。