Font J, Jiménez S, Cervera R, García-Carrasco M, Ramos-Casals M, Campdelacreu J, Ingelmo M
Systemic Autoimmune Diseases Unit, Department of Medicine, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain.
Ann Rheum Dis. 2000 Nov;59(11):920-3. doi: 10.1136/ard.59.11.920.
The main haematological manifestations seen in patients with antiphospholipid antibodies (aPL) are thrombocytopenia, usually mild, and haemolytic anaemia with a positive Coombs test. Owing to the shared characteristics with idiopathic thrombocytopenic purpura, similar rules are followed in the treatment of these cytopenias. Two patients with severe aPL associated cytopenias, who required splenectomy after being refractory to steroids, immunosuppressive agents, and other treatments (intravenous gammaglobulin, danazol), are described, and previously reported cases are reviewed.
抗磷脂抗体（aPL）患者常见的主要血液学表现为血小板减少（通常较轻）以及抗人球蛋白试验阳性的溶血性贫血。由于与特发性血小板减少性紫癜有共同特征，这些血细胞减少症的治疗遵循相似的原则。本文描述了两名患有严重aPL相关血细胞减少症的患者，他们在对类固醇、免疫抑制剂及其他治疗（静脉注射丙种球蛋白、达那唑）无效后需要进行脾切除术，并对先前报道的病例进行了回顾。
