Maddess T, James A C, Goldberg I, Wine S, Dobinson J
Centre for Visual Sciences, Research School of Biological Sciences, Australian National University, Canberra. Prince of Wales Hospital, Sydney, Australia.
Invest Ophthalmol Vis Sci. 2000 Nov;41(12):3818-26.
A pattern electroretinogram (PERG) in which stimuli displaying the frequency-doubling (FD) illusion are presented simultaneously to multiple parts of the visual field was evaluated for its ability to diagnose glaucoma. This multiregion FD PERG is referred to in the current study as the MFP.
The nine stimulus regions were temporally modulated at incommensurate frequencies typically producing an FD percept. Two other spatial scales of the stimuli were also investigated. The sensitivity and specificity of MFP were examined using linear and quadratic discriminant methods.
Even with the simpler linear discriminant classification, sensitivities and specificities of 100% were obtained in eyes with moderate to severe glaucoma. Of eyes with glaucoma strongly suspected, 67% were classified as being glaucomatous. Stimulus patterns having differing spatial scales produced different PERG visual field dependencies.
The differing results for the 16-fold change in spatial scale may reflect the accessing of different mechanisms. The MFP method appears to have significant value for the diagnosis of glaucoma.
评估一种模式视网膜电图（PERG），该PERG通过向视野的多个部分同时呈现显示倍频（FD）错觉的刺激来诊断青光眼的能力。在本研究中，这种多区域FD PERG被称为MFP。
九个刺激区域以通常产生FD感知的不相称频率进行时间调制。还研究了刺激的另外两个空间尺度。使用线性和二次判别方法检查MFP的敏感性和特异性。
即使采用更简单的线性判别分类，中度至重度青光眼患者的敏感性和特异性也达到了100%。在强烈怀疑患有青光眼的患者中，67%被分类为青光眼。具有不同空间尺度的刺激模式产生了不同的PERG视野依赖性。
空间尺度16倍变化的不同结果可能反映了不同机制的参与。MFP方法似乎对青光眼的诊断具有重要价值。
