Kawano H, Oda T, Fukunaga S, Tayama E, Kawara T, Oryoji A, Aoyagi S
Department of Surgery, Kurume University School of Medicine, Kurume, Japan.
Eur J Cardiothorac Surg. 2000 Nov;18(5):565-9. doi: 10.1016/s1010-7940(00)00570-4.
The choice of the valve substitute in the tricuspid position remains controversial. A St. Jude Medical valve is a choice of valve substitute and its lower thrombogenicity and excellent hemodynamic performance have been reported even in the tricuspid position. However, little is known of the long-term durability of the St. Jude Medical valve in the tricuspid position. Our long-term experience of tricuspid valve replacement showed the higher thrombogenicity than we had expected, therefore, this study was done to reconsider our strategy for valve choice.
This study reviewed 23 patient who underwent 25 tricuspid valve replacements with the St. Jude Medical valves from 1980 to 1997. The mean age was 40 years. Eleven patients (48%) were men. There were four in-hospital deaths (17%). The remaining 19 patients were all alive and followed from 2.2 to 19.0 years (mean 11.8 years).
The overall survival, including hospital mortality, was 83%, 10 and 15 years after surgery. Valve thrombosis occurred in six patients. Freedom from valve thrombosis was 78 and 70%, 10 and 15 years after surgery, respectively. The linearized rate of the valve thrombosis was 2.9%/patient-years. Six patients required reoperation. The mean interval to reoperation was 9.5 years. Freedom from reoperation was 83% and 75%, 10 and 15 years after surgery, respectively. The linearized rate of the reoperation was 2.8%/patient-years. No structural valve deterioration was found. Echocardiographic study showed that the function of the St. Jude Medical valve without valve-related complications was well maintained.
The higher thrombogenicity of the St. Jude Medical valve in the tricuspid position altered our choice of valve substitutes from the St. Jude Medical valve to a bioprosthesis which is lack of need for anticoagulant therapy except for juvenile patients who are able to maintain potent anticoagulant therapy.
三尖瓣位人工瓣膜的选择仍存在争议。圣犹达医疗公司生产的瓣膜是人工瓣膜的一种选择,即便在三尖瓣位,也有报道称其具有较低的血栓形成倾向和出色的血流动力学性能。然而,对于圣犹达医疗公司生产的瓣膜在三尖瓣位的长期耐用性知之甚少。我们在三尖瓣置换方面的长期经验显示,其血栓形成倾向比预期的更高,因此,开展本研究以重新审视我们的瓣膜选择策略。
本研究回顾了1980年至1997年间接受25次使用圣犹达医疗公司生产的瓣膜进行三尖瓣置换的23例患者。平均年龄为40岁。11例患者(48%)为男性。有4例住院死亡(17%)。其余19例患者均存活,随访时间为2.2至19.0年(平均11.8年)。
包括住院死亡率在内,术后10年和15年的总生存率分别为83%。6例患者发生瓣膜血栓形成。术后10年和15年无瓣膜血栓形成的比例分别为78%和70%。瓣膜血栓形成的线性化发生率为2.9%/患者年。6例患者需要再次手术。再次手术的平均间隔时间为9.5年。术后10年和15年无需再次手术的比例分别为83%和75%。再次手术的线性化发生率为2.8%/患者年。未发现结构性瓣膜退变。超声心动图研究显示,未发生瓣膜相关并发症时,圣犹达医疗公司生产的瓣膜功能维持良好。
圣犹达医疗公司生产的瓣膜在三尖瓣位具有较高的血栓形成倾向,这使我们将瓣膜替代物的选择从圣犹达医疗公司生产的瓣膜改为生物假体,除了能够维持有效抗凝治疗的青少年患者外,生物假体无需抗凝治疗。