一项关于口服与静脉注射抗生素预防下颌骨矢状劈开截骨术后感染的随机前瞻性研究。
A randomized prospective study of oral versus intravenous antibiotic prophylaxis against postoperative infection after sagittal split ramus osteotomy of the mandible.
作者信息
Yoda T, Sakai E, Harada K, Mori M, Sakamoto I, Enomoto S
机构信息
Second Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tokyo Medical and Dental University, Tokyo, Japan.
出版信息
Chemotherapy. 2000 Nov-Dec;46(6):438-44. doi: 10.1159/000007312.
BACKGROUND
We investigated whether oral levofloxacin was as effective as intravenous cefazolin sodium for preventing postoperative infections in patients undergoing sagittal split ramus osteotomy of the mandible.
METHODS
Forty-four patients were randomized to treatment with levofloxacin or cefazolin sodium. Levofloxacin (100 mg t.d.s.) was administered orally, and cefazolin sodium (1 g b.i.d.) by intravenous infusion. Both drugs were given until 5 days postoperatively. The concentrations of levofloxacin in the mandibular bone marrow and serum were measured.
RESULTS
The mean levofloxacin concentration 4 h and 53.7 min after administration was 1.086 microg/ml in serum and 1.328 microg/ml in the mandibular bone marrow. The efficacy rate of levofloxacin was 95% and that of cefazolin sodium was 85.7%, with no significant difference between the two drugs (p = 0.322).
CONCLUSION
Oral administration of levofloxacin is a simple, cost-effective and safe alternative to intravenous antibiotic prophylaxis after mandibular surgery.
背景
我们研究了口服左氧氟沙星在预防下颌骨矢状劈开截骨术患者术后感染方面是否与静脉注射头孢唑林钠同样有效。
方法
44例患者被随机分为接受左氧氟沙星或头孢唑林钠治疗组。左氧氟沙星（每日3次，每次100mg）口服给药，头孢唑林钠（每日2次，每次1g）静脉输注给药。两种药物均持续使用至术后5天。测定下颌骨骨髓和血清中左氧氟沙星的浓度。
结果
给药后4小时53分7秒，血清中左氧氟沙星的平均浓度为1.086μg/ml，下颌骨骨髓中为1.328μg/ml。左氧氟沙星的有效率为95%，头孢唑林钠为85.7%，两种药物之间无显著差异（p = 0.322）。
结论
口服左氧氟沙星是下颌骨手术后静脉使用抗生素预防感染的一种简单、经济有效且安全的替代方法。
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