Weiss H, Nehoda H, Labeck B, Oberwalder M, Konigsrainer A, Margreiter R
Department of General and Transplant Surgery, University Hospital Innsbruck, Austria.
Obes Surg. 2000 Oct;10(5):465-9. doi: 10.1381/096089200321593977.
Obesity is a prevalent health problem that has discernible impact on all fields of surgery. However, little attention is paid in the literature to the underlying relation of surgical, immunological and metabolic links between transplantation and morbid obesity. Pre-operative obesity has been reported to worsen the outcome of organ transplantation. Impairment of graft function as well as decreased patient and graft survival can contribute to this effect. Post-transplant weight gain is common and may be attributed to an imbalance of the adipostatic and appetite stimulating hormones. Reduction of obesity before transplantation has to cope with limited time, increased risk of therapeutic side-effects in patients with end-stage organ failure, and psychosocial stress. Overweight reduction following organ transplantation interferes with diverse effects associated with immunosuppressive therapy. A case of adjustable gastric banding following renal transplantation is presented.
肥胖是一个普遍存在的健康问题，对所有外科领域都有明显影响。然而，文献中很少关注移植与病态肥胖之间外科、免疫和代谢联系的潜在关系。据报道，术前肥胖会使器官移植的结果恶化。移植物功能受损以及患者和移植物存活率降低都可能导致这种情况。移植后体重增加很常见，可能归因于脂肪稳态激素和食欲刺激激素的失衡。移植前减轻肥胖必须应对时间有限、终末期器官衰竭患者治疗副作用风险增加以及心理社会压力等问题。器官移植后减轻体重会干扰与免疫抑制治疗相关的多种效应。本文介绍了一例肾移植后可调式胃束带术的病例。
