反社会行为、物质依赖与DRD5基因：一项初步研究。
Antisociality, substance dependence, and the DRD5 gene: a preliminary study.
作者信息
Vanyukov M M, Moss H B, Kaplan B B, Kirillova G P, Tarter R E
机构信息
Center for Education and Drug Abuse Research (CEDAR), University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
出版信息
Am J Med Genet. 2000 Oct 9;96(5):654-8. doi: 10.1002/1096-8628(20001009)96:5<654::aid-ajmg11>3.0.co;2-y.
A pilot population-based study of a microsatellite polymorphism at the DRD5 locus in adult European-Americans showed its association with childhood symptom counts for oppositional defiant disorder (ODD) in males and females and adult antisocial personality disorder (ASPD) in females. No association with childhood conduct disorder symptom count was observed. ODD mediated the genotype-ASPD relationship in females. Neither ODD nor ASPD significantly mediated the relationship between the genotype and the liability to substance dependence (SD). The data suggest involvement of the DRD5 locus in the variation and sexual dimorphism of SD liability and antisociality and in the developmental continuity of antisociality.
一项针对成年欧裔美国人中DRD5基因座微卫星多态性的基于人群的初步研究表明，它与男性和女性对立违抗障碍（ODD）的儿童症状计数以及女性成年反社会型人格障碍（ASPD）相关。未观察到与儿童品行障碍症状计数的关联。在女性中，ODD介导了基因型与ASPD之间的关系。ODD和ASPD均未显著介导基因型与物质依赖（SD）易感性之间的关系。数据表明DRD5基因座参与了SD易感性和反社会性的变异及性别差异，以及反社会性的发展连续性。
Zotero 插件