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草药贯叶泽兰(Eupatorium perfoliatum)叶片乙醇提取物的细胞毒性和抗菌活性

Cytotoxicity and antibacterial activity of ethanol extract from leaves of a herbal drug, boneset (Eupatorium perfoliatum).

作者信息

Habtemariam S, Macpherson A M

机构信息

School of Chemical and Life Sciences, University of Greenwich, London, UK.

出版信息

Phytother Res. 2000 Nov;14(7):575-7. doi: 10.1002/1099-1573(200011)14:7<575::aid-ptr652>3.0.co;2-1.

DOI:10.1002/1099-1573(200011)14:7<575::aid-ptr652>3.0.co;2-1
PMID:11054857
Abstract

The cytotoxic and antibacterial activity of an ethanol extract of leaves of a herbal drug, boneset (Eupatorium perfoliatum), was investigated. The extract showed potent cytotoxicity with EC(50) values (12-14 microg/mL) comparable to a standard cytotoxic agent, chlorambucil. The extract showed a weak antibacterial activity against gram-positive test organisms (Staphylococcus aureus and Bacillus megaterium).

摘要

对一种草药贯叶泽兰(Eupatorium perfoliatum)叶片的乙醇提取物的细胞毒性和抗菌活性进行了研究。该提取物表现出强大的细胞毒性,其半数有效浓度(EC50)值(12 - 14微克/毫升)与标准细胞毒性剂苯丁酸氮芥相当。该提取物对革兰氏阳性测试菌(金黄色葡萄球菌和巨大芽孢杆菌)表现出较弱的抗菌活性。

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