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Structure-based design and synthesis of phosphinate isosteres of phosphotyrosine for incorporation in Grb2-SH2 domain inhibitors. Part 2.

作者信息

Walker C V, Caravatti G, Denholm A A, Egerton J, Faessler A, Furet P, García-Echeverría C, Gay B, Irving E, Jones K, Lambert A, Press N J, Woods J

机构信息

Novartis Horsham Research Centre, West Sussex, UK.

出版信息

Bioorg Med Chem Lett. 2000 Oct 16;10(20):2343-6. doi: 10.1016/s0960-894x(00)00476-5.

DOI:10.1016/s0960-894x(00)00476-5
PMID:11055352
Abstract

A series of novel phosphinates, derived from 4-phosphonomethylphenylalanine, are described as isosteres of phosphotyrosine. Benzyl (or alkyl) phosphinomethylphenylalanine derivatives were prepared by alkylation of an amino acid P-H phosphinate.

摘要

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2
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