Fidecka S, Langwiński R
Department of Pharmacodynamics, Medical Academy, Lublin, Poland.
Pol J Pharmacol. 2000 May-Jun;52(3):187-93.
The influence of naloxone and naltrexone on the motor-impairing effects of diazepam, chlordiazepoxide, clonazepam and estazolam were studied in the aerial righting reflex test (mice, rats), and the first two drugs were examined in the rota-rod test (mice). Benzodiazepine-induced motor incoordination was significantly decreased by naloxone and naltrexone (4-16 mg/kg) in mice and rats in aerial righting reflex test. The motor-impairing effects of diazepam and chlordiazepoxide observed in rota-rod test were significantly diminished only by naltrexone (8-16 mg/kg). These data seem to confirm some interactions between benzodiazepines and opioid system.
在翻正反射试验（小鼠、大鼠）中研究了纳洛酮和纳曲酮对地西泮、氯氮卓、氯硝西泮和艾司唑仑运动损害作用的影响，并在转棒试验（小鼠）中对前两种药物进行了检测。在翻正反射试验中，纳洛酮和纳曲酮（4 - 16毫克/千克）可显著降低小鼠和大鼠中苯二氮卓类药物诱导的运动不协调。在转棒试验中观察到的地西泮和氯氮卓的运动损害作用仅被纳曲酮（8 - 16毫克/千克）显著减弱。这些数据似乎证实了苯二氮卓类药物与阿片系统之间存在一些相互作用。
