Aquino S M, Hamor R E, Valli V E, Kitchell B E, Tunev S S, Bailey K L, Ehrhart E J
Vet Pathol. 2000 Sep;37(5):465-9. doi: 10.1354/vp.37-5-465.
An 11-year-old Shetland Sheepdog was presented for exophthalmos caused by a locally extensive, poorly defined mass located behind the right eye. The primary orbital mass was identified by light microscopy and immunohistochemistry as a T-cell rich B-cell lymphoma (TCRBCL) composed predominantly of BLA.36-positive large neoplastic lymphoid cells admixed with fewer CD3- and CD79a-positive small lymphocytes. The dog was treated for lymphoma, but 6 months after presentation it was euthanatized for suspected hepatic and gastrointestinal metastasis. Gross findings revealed an enlarged liver with multiple well-demarcated, randomly distributed 0.1-1.5-cm white nodules, five firm white submucosal jejunal nodules, and ileocecal, mediastinal, and hilar lymphadenopathy. Metastatic liver lesions consisted of sheets of monomorphic large neoplastic lymphoid cells that effaced and expanded portal and centrilobular zones. These cells were morphologically similar to the large neoplastic cells of the original orbital tumor and were CD3-negative and variably BLA.36-positive, consistent with B-cell lineage. Similar cells comprised the jejunal nodules and effaced the lymph nodes. The progression of TCRBCL to a diffuse B-cell lymphoma in this case is consistent with reported human cases and has not been previously reported in the dog.
一只11岁的设得兰牧羊犬因右眼后方局部广泛、边界不清的肿块导致眼球突出前来就诊。通过光学显微镜和免疫组织化学检查，原发性眼眶肿块被确诊为富含T细胞的B细胞淋巴瘤（TCRBCL），主要由BLA.36阳性的大的肿瘤性淋巴细胞组成，混有较少的CD3和CD79a阳性的小淋巴细胞。这只狗接受了淋巴瘤治疗，但在就诊6个月后因疑似肝和胃肠道转移而实施安乐死。大体检查发现肝脏肿大，有多个界限清楚、随机分布的0.1 - 1.5厘米白色结节，五个坚实的白色空肠黏膜下结节，以及回盲部、纵隔和肺门淋巴结病。肝脏转移性病变由成片的单形性大的肿瘤性淋巴细胞组成，这些细胞取代并扩张了门静脉和小叶中心区域。这些细胞在形态上与原始眼眶肿瘤的大的肿瘤细胞相似，CD3阴性，BLA.36阳性情况不一，符合B细胞谱系。类似的细胞构成了空肠结节并取代了淋巴结。在这种情况下，TCRBCL进展为弥漫性B细胞淋巴瘤，与已报道的人类病例一致，此前在犬类中尚未见报道。
