Hilbe M, Sydler T, Fischer L, Naegeli H
Vet Pathol. 2000 Sep;37(5):490-2. doi: 10.1354/vp.37-5-490.
A 22-week-old 21-kg female Bernese Mountain Dog ingested a topical antipsoriatic preparation containing the synthetic vitamin D analog tacalcitol. The dog died after a history of lethargy, recumbency, paresis of the hindlimbs, increased rectal temperature, dyspnea, and hematemesis. Histologic examination revealed metastatic calcification in the kidneys, lungs, myocardium, brain, stomach, and tear glands. The appearance of soft tissue mineralization in multiple organs is consistent with hypercalcemia derived from excessive vitamin D uptake. Oral toxicity studies for tacalcitol in the dog are not available, but the present report emphasizes the extraordinary toxic risk of drugs containing this vitamin D analog to dogs.
一只22周龄、体重21千克的雌性伯恩山犬摄入了一种含有合成维生素D类似物他卡西醇的外用抗银屑病制剂。这只狗在出现嗜睡、卧地不起、后肢麻痹、直肠温度升高、呼吸困难和呕血等症状后死亡。组织学检查显示，肾脏、肺、心肌、脑、胃和泪腺出现转移性钙化。多个器官出现软组织矿化的表现与因过量摄入维生素D导致的高钙血症相符。目前尚无关于他卡西醇对犬类的口服毒性研究，但本报告强调了含这种维生素D类似物的药物对犬类具有极高的毒性风险。
