他莫昔芬对子宫内膜转化生长因子β（TGFβ）的调节作用

Modulation of endometrial transforming growth factor beta (TGFbeta) by tamoxifen.

作者信息

Carmichael P L, Pole J C, Neven P

机构信息

Imperial College School of Medicine, Molecular Toxicology, Sir Alexander Fleming Building, South Kensington, SW7 2AZ, London, UK.

出版信息

Eur J Cancer. 2000 Sep;36 Suppl 4:S42-3. doi: 10.1016/s0959-8049(00)00220-3.

DOI:10.1016/s0959-8049(00)00220-3

PMID:11056313

Abstract

Transforming growth factor beta (TGFbeta) immunoreactivity was determined in endometria from non-drug-therapy and tamoxifen-treated patients. Sections were scored for pathology and quantity image analysis performed to determine levels of glandular- or fibrosis-associated TGFbeta1. Tamoxifen-treated patients displayed greater levels of endometrial dysplasia and glandular hyperplasia, in addition to a statistically significant (P<0.0001) elevation in gland-associated TGFbeta1 protein.

摘要

在未接受药物治疗和接受他莫昔芬治疗的患者的子宫内膜中测定转化生长因子β（TGFβ）免疫反应性。对切片进行病理学评分，并进行定量图像分析以确定与腺体或纤维化相关的TGFβ1水平。除了与腺体相关的TGFβ1蛋白有统计学显著升高（P<0.0001）外，接受他莫昔芬治疗的患者还表现出更高水平的子宫内膜发育异常和腺体增生。