体内免疫消融和体外单核细胞清除后难治性自身免疫性疾病的自体干细胞移植。
Autologous stem-cell transplantation in refractory autoimmune diseases after in vivo immunoablation and ex vivo depletion of mononuclear cells.
作者信息
Rosen O, Thiel A, Massenkeil G, Hiepe F, Häupl T, Radtke H, Burmester G R, Gromnica-Ihle E, Radbruch A, Arnold R
机构信息
Department of Oncology/Haematology, University Hospital Charité (Campus Mitte), Berlin, Germany.
出版信息
Arthritis Res. 2000;2(4):327-36. doi: 10.1186/ar107. Epub 2000 Jun 8.
Abstract
Autoimmune diseases that are resistant to conventional treatment cause severe morbidity and even mortality. In the present study we demonstrate that complete remissions can be achieved in refractory polychondritis and systemic lupus erythematosus (SLE), even at advanced stage, with the use of autologous stem-cell transplantation (SCT). Remissions persisted after reconstitution of the immune system. In the treatment of advanced systemic sclerosis (SSc), stable disease may be achieved with autologous SCT.
摘要
对传统治疗有抗性的自身免疫性疾病会导致严重发病甚至死亡。在本研究中，我们证明，使用自体干细胞移植（SCT），即使在晚期，难治性多软骨炎和系统性红斑狼疮（SLE）也可实现完全缓解。免疫系统重建后缓解仍持续存在。在晚期系统性硬化症（SSc）的治疗中，自体SCT可实现病情稳定。
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