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类风湿性关节炎滑膜中单个CD4(+)记忆T细胞的细胞因子、激活标志物及趋化因子受体表达

Cytokine, activation marker, and chemokine receptor expression by individual CD4(+) memory T cells in rheumatoid arthritis synovium.

作者信息

Nanki T, Lipsky P E

机构信息

Department of Internal Medicine and Harold C Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.

出版信息

Arthritis Res. 2000;2(5):415-23. doi: 10.1186/ar120. Epub 2000 Jul 3.

DOI:10.1186/ar120
PMID:11056676
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC17818/
Abstract

IL-10, IL-13, IFN-gamma, tumor necrosis factor (TNF)-alpha, LT-alpha, CD154, and TNF-related activation-induced cytokine (TRANCE) were expressed by 2-20% of rheumatoid arthritis (RA) synovial tissue CD4(+) memory T cells, whereas CD4(+) cells that produced IL-2, IL-4, or IL-6 were not detected. Expression of none of these molecules by individual CD4(+) cells correlated with the exception of TRANCE and IL-10, and TRANCE and TNF-alpha. A correlation between expression of IL-10 and CCR7, LT-alpha and CCR6, IFN-gamma and CCR5, and TRANCE and CXCR4 was also detected.

摘要

白细胞介素-10（IL-10）、白细胞介素-13（IL-13）、γ干扰素（IFN-γ）、肿瘤坏死因子（TNF）-α、淋巴毒素-α（LT-α）、CD154和肿瘤坏死因子相关激活诱导细胞因子（TRANCE）在2%至20%的类风湿关节炎（RA）滑膜组织CD4(+)记忆T细胞中表达，而未检测到产生白细胞介素-2（IL-2）、白细胞介素-4（IL-4）或白细胞介素-6的CD4(+)细胞。除TRANCE与IL-10以及TRANCE与TNF-α外，单个CD4(+)细胞对这些分子的表达均无相关性。还检测到IL-10与CCR7、LT-α与CCR6、IFN-γ与CCR5以及TRANCE与CXCR4表达之间的相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4a3/17818/f1f5fed233ec/ar-2-5-415-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4a3/17818/f1f5fed233ec/ar-2-5-415-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4a3/17818/f1f5fed233ec/ar-2-5-415-1.jpg

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