新型合成类固醇的抗雄激素作用

Antiandrogenic effect of new synthetic steroids.

作者信息

Cabeza M, Quiroz A, Heuze I, Bratoeff E, Herrera H, Ramírez E, Murillo E

机构信息

Department of Biological Systems, Agricultural and Animal Production Metropolitan University-Xochimilco, Mexico, D.F.

出版信息

Proc West Pharmacol Soc. 2000;43:31-2.

PMID:11056950

Abstract

These results indicate that castration decreased the flank organ diameter and the weight of the seminal vesicles, whereas daily injection of testosterone restores them. However injections of finasteride together with testosterone inhibited the diameter of the flank organs, the weight of the seminal vesicles, and the conversion of testosterone to dihydrotestosterone. The four compounds tested inhibited flank organ diameter size and the weight of the seminal vesicles as compared to the testosterone-treated animals. On the other hand, none of these compounds suppressed the conversion of testosterone to dihydrotestosterone. These results suggest that the synthesized steroids compete with androgen receptors.

摘要

这些结果表明，去势降低了腹侧器官直径和精囊重量，而每日注射睾酮可使其恢复。然而，非那雄胺与睾酮一起注射会抑制腹侧器官直径、精囊重量以及睾酮向二氢睾酮的转化。与接受睾酮治疗的动物相比，所测试的四种化合物均抑制了腹侧器官直径大小和精囊重量。另一方面，这些化合物均未抑制睾酮向二氢睾酮的转化。这些结果表明，合成类固醇与雄激素受体存在竞争。