吡哌酸与萘啶酸的体外抗菌活性（作者译）

[Antibacterial in-vitro activity of pipemidic acid and nalidixic acid (author's transl)].

作者信息

Peters G, Freiesleben H, Marre R, Metz H, Tannenberg H, Pulverer G

出版信息

Dtsch Med Wochenschr. 1979 Jun 29;104(26):946-8. doi: 10.1055/s-0028-1104021.

Abstract

The in-vitro activity of nalidixic acid and pipemidic acid was investigated in a combined study in 450 freshly isolated bacterial strains using the agar dilution test. Gram-positive cocci were resistant to both substances except for a few pipemidic acid sensitive staphylococci. Both substances had good antibacterial activity in the gram-negative spectrum. However, the MIC values of pipemidic acid were generally clearly lower than those of nalidixic acid. Only pipemidic acid showed activity against Pseudomonas aeruginosa. Thus the in-vitro results showed that pipemidic acid has clear-cut and valuable advantages for the treatment of urinary tract infections when compared with nalidixic acid.

摘要

采用琼脂稀释法，在一项联合研究中对450株新分离的细菌菌株检测了萘啶酸和吡哌酸的体外活性。除少数对吡哌酸敏感的葡萄球菌外，革兰氏阳性球菌对这两种药物均耐药。这两种药物在革兰氏阴性菌谱中均具有良好的抗菌活性。然而，吡哌酸的最低抑菌浓度（MIC）值通常明显低于萘啶酸。只有吡哌酸对铜绿假单胞菌有活性。因此，体外实验结果表明，与萘啶酸相比，吡哌酸在治疗尿路感染方面具有明显且有价值的优势。