Schaefer A, Kremp S, Hellwig D, Alexander C, Kirsch C M
Abteilung für Nuklearmedizin, Radiologischen Klinik der Universitätskliniken des Saarlandes, Homburg/Saar, Deutschland.
Nuklearmedizin. 2000 Sep;39(6):156-65.
The aim was to study the influence of single-photon-transmission scan duration in 3D-PET on the quantitative values of attenuation coefficients and noise in transmission images and of activity concentrations and noise in attenuation corrected emission images of thorax phantom- and patient data.
Using dual collimated Cs-137 singles transmission sources (E gamma = 662 KeV, A = 2* 614 MBq) on an ECAT ART tomograph series of transmission scans of a thorax phantom were acquired pre- and post-injection of 18F. 17 patients underwent two transmission scans. The scan time of the short transmission was chosen according to the results of the phantom studies (noise of Poisson statistics less than 4%). Transmission and attenuation corrected emission images were evaluated with respect to estimated linear attenuation coefficients, noise and specific activities in organs.
The phantom studies reveal little variation of the estimated linear attenuation coefficients as a function of scan duration. The estimates of the attenuation coefficients are found to be 1% lower than the expected values for pre- and up to 6.5% lower for post-injection transmissions. The noise level in the transmission images increases as expected for Poisson data. The noise level in the attenuation corrected emission images shows only little increase with decreasing transmission scan time whereas it is strongly influenced by a variation of emission scan time. In patient studies, less than 3% difference was found in the estimated linear attenuation coefficients as well as in the activity concentrations between short (pre or post-injection) and long transmission scans. The noise levels in transmission and emission images are 1% (pre-injection) and 4% (post-injection) higher for short transmission scans.
Due to the high photon flux, single photon transmission offers good clinical performance with significantly reduced transmission scan durations (< 2 min/bed in pre-, < 4 min/bed in post-injection transmission).
研究三维正电子发射断层显像(3D-PET)中单次光子传输扫描时间对胸部体模和患者数据的透射图像中衰减系数及噪声、衰减校正发射图像中活度浓度及噪声定量值的影响。
在ECAT ART断层扫描仪上使用双准直Cs-137单光子发射源(Eγ = 662 keV,A = 2×614 MBq),在注射18F前后对胸部体模进行一系列透射扫描。17名患者接受了两次透射扫描。短透射扫描时间根据体模研究结果选择(泊松统计噪声小于4%)。对透射和衰减校正发射图像进行评估,分析器官中估计的线性衰减系数、噪声和比活度。
体模研究表明,估计的线性衰减系数随扫描时间变化不大。发现注射前衰减系数估计值比预期值低1%,注射后透射扫描低至6.5%。透射图像中的噪声水平如泊松数据预期那样增加。衰减校正发射图像中的噪声水平随透射扫描时间减少仅略有增加,而受发射扫描时间变化影响较大。在患者研究中,短(注射前或注射后)和长透射扫描之间估计的线性衰减系数以及活度浓度差异小于3%。短透射扫描时,透射和发射图像中的噪声水平分别比长透射扫描高1%(注射前)和4%(注射后)。
由于光子通量高,单光子传输在显著缩短透射扫描时间(注射前<2分钟/床位,注射后<4分钟/床位)的情况下仍具有良好的临床性能。